Twist Bioscience Stock Plummets Over 12%, on Pace for Worst Day in a Year
The biotech firm's shares hit a new low for 2025, continuing a sharp downtrend from its all-time high and marking a challenging year for investors.
SAN FRANCISCO – Shares of Twist Bioscience Corp. (NASDAQ: TWST) experienced a significant sell-off in trading today, tumbling more than 12% and placing the stock on a path toward one of its worst single-day performances in the past year.
As of 1:11 PM ET, TWST stock was trading at $29.50, a sharp decline of $4.19, or 12.43%. The sell-off has pushed the company’s shares to levels not seen in over a year. If the stock closes at its current price, it would mark its lowest finish since May 30, 2025, when it closed at $29.30.
The magnitude of today’s drop is notable. It represents the stock’s largest single-day percentage decrease since August 2, 2024, when it fell 19%. This latest decline extends a period of recent weakness, with the stock now down in three of the past five trading sessions.
A Challenging Year in a Broader Context
Zooming out, the broader picture for Twist Bioscience investors has been challenging. The stock is now down 36.53% year-to-date. This performance is part of a much larger, prolonged downtrend from its pandemic-era peak.
The current price reflects a staggering 85.82% fall from its all-time closing high of $207.97, reached on January 20, 2021. This starkly illustrates the shift in investor sentiment and valuation for the synthetic biology company over the last few years.
Looking at its performance over the last 12 months:
The stock is down 34.93% from where it stood a year ago (August 5, 2024).
It has fallen 45.45% from its 52-week closing high of $54.07, set on January 24, 2025.
Intraday Volatility and Key Levels
The intraday volatility has been particularly severe. At its lowest point today, Twist Bioscience traded down to $27.52, its lowest intraday level since May 23, 2025. This trough represented an 18.29% drop for the session.
Despite the punishing decline, the stock remains narrowly above its 52-week closing low of $28.16, which was recorded on May 22, 2025. At its current price of $29.50, it is still trading 4.74% above that floor, a key technical level that investors will be watching closely.
Today’s trading activity underscores a difficult period for Twist Bioscience, as the stock struggles against significant selling pressure and marks several grim milestones for its long-term performance.
